The death of a man at tourism spot Hanging Rock on Friday afternoon has prompted the closure of the reserve over the long weekend.

Victoria Police said man was died after he fell while climbing onto a rock at the summit of the volcanic formation, which lies 75 kilometres north-west of Melbourne.

The man fell just before 1pm.

"Despite the efforts of several off-duty medical professionals at the scene, the man was unable to be revived and was declared deceased at the scene," a police spokesperson said.

Hanging Rock Reserve was closed on Friday and will remain so on Saturday September 26, according to the Macedon Ranges Shire Council.

The council cited a medical incident as the reason for the closure.

The Grand Final Eve public holiday on Friday made the AFL Grand Final weekend a three-day break for many Victorians.

Police will prepare a report for the coroner.